The following questions give examples to use this new feature:
FTP example: How to create a pass through channel to handle moving large files?
File example: How to move large files with a File source node?
Network Share example: How to move large files with a Network Share source node?
In addition to the above that focus on the "Large File Handling Options" You might find this question helpful if you need to configure an FTP source maually using the "Custom Apache Camel parameters":
Alternate to using "Large File Handling Options" for FTP?
You might find this question to be helpful if you need to process large files line by line:
How can I read a 30GB CSV file into QIE